Identification of Determinants Required for Agonistic and Inverse Agonistic Ligand Properties at the ADP Receptor P2Y12
نویسندگان
چکیده
منابع مشابه
Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12.
The ADP receptor P2Y(12) belongs to the superfamily of G protein-coupled receptors (GPCRs), and its activation triggers platelet aggregation. Therefore, potent antagonists, such as clopidogrel, are of high clinical relevance in prophylaxis and treatment of thromboembolic events. P2Y(12) displays an elevated basal activity in vitro, and as such, inverse agonists may be therapeutically beneficial...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2012
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.112.082198